Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in stroke treatment and prevention.

ABSTRACT: Annually, tens of millions of first-ever strokes occur in the world; however, currently there is lack of effective and widely applicable pharmacological treatments for stroke patients. Herbal medicines, characterized as multi-constituent, multi-target and multi-effect, have been acknowledged with conspicuous effects in treating stroke, and attract extensive interest of researchers although the mechanism of action is yet unclear. In this work, we introduce an innovative systems-pharmacology method that combines pharmacokinetic prescreening, target fishing and network analysis to decipher the mechanisms of action of 10 herbal medicines like Salvia miltiorrhizae, Ginkgo biloba and Ephedrae herba which are efficient in stroke treatment and prevention. Our systematic analysis results display th

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4122378 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature