Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds.

ABSTRACT: A virus-activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high-density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs.

SUBMITTER: Wang J 

PROVIDER: S-EPMC4122615 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature