Association between in vitro susceptibility to natamycin and voriconazole and clinical outcomes in fungal keratitis.

ABSTRACT:

Purpose

To assess the association between minimum inhibitory concentration (MIC) and clinical outcomes in a fungal keratitis clinical trial.

Design

Experimental study using data from a randomized comparative trial.

Participants

Of the 323 patients enrolled in the trial, we were able to obtain MIC values from 221 patients with monocular fungal keratitis.

Methods

The Mycotic Ulcer Treatment Trial I was a randomized, double-masked clinical trial comparing clinical outcomes of monotherapy with topical natamycin versus voriconazole for the treatment of fungal keratitis. Speciation and determination of MIC to natamycin and voriconazole were performed according to Clinical and Laboratory Standards Institute guidelines. The relationship between MIC and clinical outcome

SUBMITTER: Sun CQ 

PROVIDER: S-EPMC4122634 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature