Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis.

ABSTRACT:

Objectives

To determine whether BCG vaccination protects against Mycobacterium tuberculosis infection as assessed by interferon γ release assays (IGRA) in children.

Design

Systematic review and meta-analysis. Searches of electronic databases 1950 to November 2013, checking of reference lists, hand searching of journals, and contact with experts.

Setting

Community congregate settings and households.

Inclusion criteria

Vaccinated and unvaccinated children aged under 16 with known recent exposure to patients with pulmonary tuberculosis. Children were screened for infection with M tuberculosis with interferon γ release assays.

Data extraction

Study results relating to diagnostic accuracy were extracted and risk estimates were combined with random effects met

SUBMITTER: Roy A 

PROVIDER: S-EPMC4122754 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature