The changing incidence of dengue haemorrhagic fever in Indonesia: a 45-year registry-based analysis.

ABSTRACT:

Background

Increases in human population size, dengue vector-density and human mobility cause rapid spread of dengue virus in Indonesia. We investigated the changes in dengue haemorrhagic fever (DHF) incidence in Indonesia over a 45-year period and determined age-specific trends in annual DHF incidence.

Methods

Using an on-going nationwide dengue surveillance program starting in 1968, we evaluated all DHF cases and related deaths longitudinally up to 2013. Population demographics were used to calculate annual incidence and case fatality ratios (CFRs). Age-specific data on DHF available from 1993 onwards were used to assess trends in DHF age-distribution. Time-dependency of DHF incidence and CFRs was assessed using the Cochrane-Armitage trend test.

Results

The annual D

SUBMITTER: Karyanti MR 

PROVIDER: S-EPMC4122763 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature