Gross cystic disease fluid protein 15 (GCDFP-15) expression in breast cancer subtypes.

ABSTRACT:

Background

Gross cystic disease fluid protein 15 (GCDFP-15), which is regulated by the androgen receptor (AR), is a diagnostic marker for mammary differentiation in histopathology. We determined the expression of GCDFP-15 in breast cancer subtypes, its potential prognostic and predictive value, as well as its relationship to AR expression.

Methods

602 pre-therapeutic breast cancer core biopsies from the phase III randomized neoadjuvant GeparTrio trial (NCT00544765) were investigated for GCDFP-15 expression by immunohistochemistry. Expression data were correlated with disease-free (DFS) and overall survival (OS) time as well as pathological complete response (pCR) to neoadjuvant chemotherapy.

Results

239 tumors (39.7%) were GCDFP-15 positive. GCDFP-15 expression was po

SUBMITTER: Darb-Esfahani S 

PROVIDER: S-EPMC4122770 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature