Transcriptional landscape of repetitive elements in normal and cancer human cells.

ABSTRACT:

Background

Repetitive elements comprise at least 55% of the human genome with more recent estimates as high as two-thirds. Most of these elements are retrotransposons, DNA sequences that can insert copies of themselves into new genomic locations by a "copy and paste" mechanism. These mobile genetic elements play important roles in shaping genomes during evolution, and have been implicated in the etiology of many human diseases. Despite their abundance and diversity, few studies investigated the regulation of endogenous retrotransposons at the genome-wide scale, primarily because of the technical difficulties of uniquely mapping high-throughput sequencing reads to repetitive DNA.

Results

Here we develop a new computational method called RepEnrich to study genome-wide transcri

SUBMITTER: Criscione SW 

PROVIDER: S-EPMC4122776 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature