Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta.

ABSTRACT:

Background

Prenatal exposure to endocrine disrupting compounds (EDCs) has previously shown to alter epigenetic marks.

Objectives

In this work we explore whether prenatal exposure to mixtures of xenoestrogens has the potential to alter the placenta epigenome, by studying DNA methylation in retrotransposons as a surrogate of global DNA methylation.

Methods

The biomarker total effective xenoestrogen burden (TEXB) was measured in 192 placentas from participants in the longitudinal INMA Project. DNA methylation was quantitatively assessed by bisulfite pyrosequencing on 10 different retrotransposons including 3 different long interspersed nuclear elements (LINEs), 4 short interspersed nuclear elements (SINEs) and 3 human endogenous retroviruses (HERVs). Associations were te

SUBMITTER: Vilahur N 

PROVIDER: S-EPMC4122792 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature