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EC-BLAST: a tool to automatically search and compare enzyme reactions.


ABSTRACT: We present EC-BLAST (http://www.ebi.ac.uk/thornton-srv/software/rbl/), an algorithm and Web tool for quantitative similarity searches between enzyme reactions at three levels: bond change, reaction center and reaction structure similarity. It uses bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping across each reaction. EC-BLAST has the potential to improve enzyme classification, identify previously uncharacterized or new biochemical transformations, improve the assignment of enzyme function to sequences, and assist in enzyme engineering.

SUBMITTER: Rahman SA 

PROVIDER: S-EPMC4122987 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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EC-BLAST: a tool to automatically search and compare enzyme reactions.

Rahman Syed Asad SA   Cuesta Sergio Martinez SM   Furnham Nicholas N   Holliday Gemma L GL   Thornton Janet M JM  

Nature methods 20140112 2


We present EC-BLAST (http://www.ebi.ac.uk/thornton-srv/software/rbl/), an algorithm and Web tool for quantitative similarity searches between enzyme reactions at three levels: bond change, reaction center and reaction structure similarity. It uses bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping across each reaction. EC-BLAST has the potential to improve enzyme classification, identify previously uncharacterized or new biochemical transformati  ...[more]

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