Ontology highlight
ABSTRACT:
SUBMITTER: Patel AP
PROVIDER: S-EPMC4123637 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140612 6190
Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect tumor composition in patients. We used single-cell RNA sequencing (RNA-seq) to profile 430 cells from five primary glioblastomas, which we found to be inherently variable in their expression of diverse transcriptional programs related to oncogenic signaling, proliferation, complement/immune response, and hypoxia. We also observed a contin ...[more]