Ontology highlight
ABSTRACT:
SUBMITTER: Cimermancic P
PROVIDER: S-EPMC4123684 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Cell 20140701 2
Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial metabolites, our knowledge of their diversity remains limited. Here, we used a novel algorithm to systematically identify BGCs in the extensive extant microbial sequencing data. Network analysis of the predicted BGCs revealed large gene cluster families, the vast majority uncharacterized. We experimentally characterized the most prominent family, consisting of two subfamilies of hundreds of BGCs distributed ...[more]