Cholinesterase and paraoxonase (PON1) enzyme activities in Mexican-American mothers and children from an agricultural community.

ABSTRACT: Exposure to organophosphate and carbamate pesticides can lead to neurotoxic effects through inhibition of cholinesterase enzymes. The paraoxonase (PON1) enzyme can detoxify oxon derivatives of some organophosphates. Lower PON1, acetylcholinesterase, and butyrylcholinesterase activities have been reported in newborns relative to adults, suggesting increased susceptibility to organophosphate exposure in young children. We determined PON1, acetylcholinesterase, and butyrylcholinesterase activities in Mexican-American mothers and their 9-year-old children (n=202 pairs) living in an agricultural community. We used Wilcoxon signed-rank tests to compare enzymatic activities among mothers and their children, and analysis of variance to identify factors associated with enzyme activities. Substrate-

SUBMITTER: Gonzalez V 

PROVIDER: S-EPMC4123814 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature