MicroRNA-21 identified as predictor of cancer outcome: a meta-analysis.

ABSTRACT:

Background

Growing evidence from recent studies has revealed the association of microRNA-21 (mir-21) with outcomes in multiple cancers, but inconsistent findings have been reported, which rationalized a summary and analysis of available data to investigate the prognostic role of mir-21.

Materials and methods

Eligible studies were identified through several search strategies and assessed for quality. Data was extracted from studies in terms of baseline characteristics and key statistics such as hazard ratio (HR), 95% confidence interval (CI) and P value, which were utilized to calculate pooled effect size.

Results

25 studies were included in the meta-analysis to evaluate the prognostic role of mir-21 in malignant tumors. Elevated mir-21 level was demonstrated to modera

SUBMITTER: Zhu W 

PROVIDER: S-EPMC4123876 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature