The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders.

ABSTRACT:

Purpose of review

Genomic imprinting refers to preferential allele-specific gene expression. DNA methylation-based molecular mechanisms regulate establishment and maintenance of parental imprints during early embryo development and gametogenesis. Because of the coincident timing, a potential association between assisted reproductive technology (ART) procedures and imprinting defects has been investigated in various studies. In this review, we provide an overview of genomic imprinting and present a summary of the relevant clinical data.

Recent findings

ART procedures affect DNA methylation pattern, parental imprinting status, and imprinted gene expression in the mouse embryo. In humans, several case series suggested an association between ART and imprinting disorders, with a

SUBMITTER: Uyar A 

PROVIDER: S-EPMC4123998 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature