Dataset Information

Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: implications for radiation therapy planning.

ABSTRACT:

Background and purpose

This study seeks to: (a) quantify radiologic-pathologic discrepancy for pancreatic adenocarcinoma by comparing tumor size on conventional computed tomography (C-CT) and 3-dimensional CT (3D-CT) to corresponding pathologic specimens; and (b) to identify clinico-pathologic characteristics predictive of radiologic-pathologic discrepancy to assist radiotherapy planning.

Materials and methods

Sixty-three patients with pancreatic adenocarcinoma and preoperative C-CT and volume-rendered 3D-CT imaging within 6 weeks of resection were identified. Maximum tumor diameter (MTD) was measured on pathology, C-CT, and 3D-CT and compared for each patient as well as among different clinico-pathologic subgroups.

Results

There was a trend toward C-CT underestimation of MTD compared to final pathology (p=0.08), but no significant difference between 3D-CT MTD and pathology (p=0.54). Pathologic tumor size was significantly underestimated by C-CT in patients with larger pathologic tumor size (>3.0 cm, p=0.0001), smaller tumor size on C-CT (<3.0 cm, p=0.003), higher CA19-9 (>90 U/mL, p=0.008), and location in the pancreatic head (p=0.015). A model for predicting pathologic MTD using C-CT MTD and CA19-9 level was generated.

Conclusions

3D-CT may allow for more accurate contouring of pancreatic tumors than C-CT. Patients with the above clinico-pathologic characteristics may require expanded margins relative to tumor size estimates on C-CT during radiotherapy planning.

SUBMITTER: Qiu H

PROVIDER: S-EPMC4124599 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Publications

Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: implications for radiation therapy planning.

Qiu Haoming H Wild Aaron T AT Wang Hao H Fishman Elliot K EK Hruban Ralph H RH Laheru Daniel A DA Kumar Rachit R Hacker-Prietz Amy A Tuli Richard R Tryggestad Erik E Schulick Richard D RD Cameron John L JL Edil Barish H BH Pawlik Timothy M TM Wolfgang Christopher L CL Herman Joseph M JM

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20120808 2

<h4>Background and purpose</h4>This study seeks to: (a) quantify radiologic-pathologic discrepancy for pancreatic adenocarcinoma by comparing tumor size on conventional computed tomography (C-CT) and 3-dimensional CT (3D-CT) to corresponding pathologic specimens; and (b) to identify clinico-pathologic characteristics predictive of radiologic-pathologic discrepancy to assist radiotherapy planning.<h4>Materials and methods</h4>Sixty-three patients with pancreatic adenocarcinoma and preoperative C- ...[more]

PMID: 22883106

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Dataset Information

Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: implications for radiation therapy planning.

Background and purpose

Materials and methods

Results

Conclusions

Publications

Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: implications for radiation therapy planning.

Similar Datasets

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