Current status of immunological therapies for prostate cancer.

ABSTRACT:

Purpose of review

Considerable progress has been made in prostate cancer immunotherapy over the last year, and two agents have completed phase III testing. This review will discuss the most promising immune-directed strategies in development for prostate cancer, outlining interventions that mitigate tumor-induced tolerance and highlighting several combination immunotherapy approaches.

Recent findings

A pivotal phase III study using Sipuleucel-T, an autologous prostatic acid phosphatase (PAP)-loaded dendritic cell immunotherapy, in men with metastatic castration-resistant prostate cancer (CRPC) demonstrated a survival advantage over placebo. By contrast, two phase III studies of GVAX, an allogeneic tumor cell vaccine, in a similar patient population failed to show a survival

SUBMITTER: Antonarakis ES 

PROVIDER: S-EPMC4124631 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature