Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level.

ABSTRACT:

Objective

We evaluated the association of single nucleotide polymorphisms (SNPs) in TLRs with infant HIV-1 acquisition and viral control.

Design

Infant HIV-1 outcomes were assessed in a Kenyan perinatal HIV-1 cohort.

Methods

Infants were genotyped for six candidate and 118 haplotype-tagging polymorphisms in TLRs 2, 3, 4, 7, 8, and 9, MYD88 and TIRAP. Cox proportional hazards and linear regression were performed to assess associations with time to HIV-1 acquisition, time to infant mortality, and peak viral load.

Results

Among 368 infants, 56 (15%) acquired HIV-1 by month 1 and 17 (4.6%) between 1 and 12 months. Infants with the TLR9 1635A (rs352140) variant were more likely to acquire HIV-1 by 1 month [hazard ratio = 1.81, 95% confidence interval (CI) = 1.05-3.1

SUBMITTER: Beima-Sofie KM 

PROVIDER: S-EPMC4124859 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature