Synthesis of a Macrocycle Based on Linked Amino Acid Mimetics (LAAM).

ABSTRACT: We report the synthesis of a macrocycle utilizing a novel framework of standard amino acids in combination with subunits that we have named as Linked Amino Acid Mimetics (LAAM's). Macrocycles based on the LAAM concept provide both a peptide targeting region and two independently variable functional regions. In the prototype structure, the commonly known Arg-Gly-Asp (RGD) sequence was used for the targeting region. The functional regions contain a phenyl group, and the linkage was formed via a Ring-Closing Metathesis (RCM) reaction.

SUBMITTER: Maxwell DS 

PROVIDER: S-EPMC4125026 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature