Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice.

ABSTRACT:

Background

Continuous support from follicular CD4(+) T helper (Tfh) cells drives germinal center (GC) responses, which last for several weeks to produce high affinity memory B cells and plasma cells. In autoimmune Sle1 and NZB/W F1 mice, elevated numbers of Tfh cells persist, promoting the expansion of self-reactive B cells. Expansion of circulating Tfh like cells have also been described in several autoimmune diseases. Although, the signals required for Tfh differentiation have now been well described, the mechanisms that sustain the maintenance of fully differentiated Tfh are less understood. Recent data demonstrate a role for GC B cells for Tfh maintenance after protein immunization.

Methods and finding

Given the pathogenic role Tfh play in autoimmune disease, we explored

SUBMITTER: Yusuf I 

PROVIDER: S-EPMC4125140 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature