Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-sequencing.

ABSTRACT: The liver plays a central role in metabolic homeostasis by coordinating synthesis, storage, breakdown, and redistribution of nutrients. Hepatic energy metabolism is dynamically regulated throughout different life stages due to different demands for energy during growth and development. However, changes in gene expression patterns throughout ontogeny for factors important in hepatic energy metabolism are not well understood. We performed detailed transcript analysis of energy metabolism genes during various stages of liver development in mice. Livers from male C57BL/6J mice were collected at twelve ages, including perinatal and postnatal time points (n = 3/age). The mRNA was quantified by RNA-Sequencing, with transcript abundance estimated by Cufflinks. One thousand sixty energy metabolism

SUBMITTER: Renaud HJ 

PROVIDER: S-EPMC4125194 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature