Pleiotropy can be effectively estimated without counting phenotypes through the rank of a genotype-phenotype map.

ABSTRACT: Although pleiotropy, the capability of a gene to affect multiple phenotypes, has been well known as one of the common gene properties, a quantitative estimation remains a great challenge, simply because of the phenotype complexity. Not surprisingly, it is hard for general readers to understand how, without counting phenotypes, gene pleiotropy can be effectively estimated from the genetics data. In this article we extensively discuss the Gu-2007 method that estimated pleiotropy from the protein sequence analysis. We show that this method is actually to estimate the rank (K) of genotype-phenotype mapping that can be concisely written as K = min(r, Pmin), where Pmin is the minimum pleiotropy among all legitimate measures including the fitness components, and r is the rank of mutational effect

SUBMITTER: Gu X 

PROVIDER: S-EPMC4125405 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature