A biphasic multiscale study of the mechanical microenvironment of chondrocytes within articular cartilage under unconfined compression.

ABSTRACT: Computational analyses have been used to study the biomechanical microenvironment of the chondrocyte that cannot be assessed by in vitro experimental studies; yet all computational studies thus far have focused on the effect of zonal location (superficial, middle, and deep) on the mechanical microenvironment of chondrocytes. The aim of this paper was to study the effect of both zonal and radial locations on the biomechanical microenvironment of chondrocytes in inhomogeneous cartilage under unconfined stress relaxation. A biphasic multiscale approach was employed and nine chondrocytes in different locations were studied. Hyperelastic biphasic theory and depth-dependent aggregate modulus and permeability of articular cartilage were included in the models. It was found that both zonal and rad

SUBMITTER: Guo H 

PROVIDER: S-EPMC4125488 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature