APOε4 is associated with enhanced in vivo innate immune responses in human subjects.

ABSTRACT:

Background

The genetic determinants of the human innate immune response are poorly understood. Apolipoprotein (Apo) E, a lipid-trafficking protein that affects inflammation, has well-described wild-type (ε3) and disease-associated (ε2 and ε4) alleles, but its connection to human innate immunity is undefined.

Objective

We sought to define the relationship of APOε4 to the human innate immune response.

Methods

We evaluated APOε4 in several functional models of the human innate immune response, including intravenous LPS challenge in human subjects, and assessed APOε4 association to organ injury in patients with severe sepsis, a disease driven by dysregulated innate immunity.

Results

Whole blood from healthy APOε3/APOε4 volunteers induced higher cytokine levels on e

SUBMITTER: Gale SC 

PROVIDER: S-EPMC4125509 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature