Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.

ABSTRACT: Hematopoiesis is an exquisitely regulated process in which stem cells in the developing embryo and the adult generate progenitor cells that give rise to all blood lineages. Master regulatory transcription factors control hematopoiesis by integrating signals from the microenvironment and dynamically establishing and maintaining genetic networks. One of the most rudimentary aspects of cell type-specific transcription factor function, how they occupy a highly restricted cohort of cis-elements in chromatin, remains poorly understood. Transformative technologic advances involving the coupling of next-generation DNA sequencing technology with the chromatin immunoprecipitation assay (ChIP-seq) have enabled genome-wide mapping of factor occupancy patterns. However, formidable problems remain; nota

SUBMITTER: DeVilbiss AW 

PROVIDER: S-EPMC4125519 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature