Weight Loss Programs May Have Beneficial or Adverse Effects on Fat Mass and Insulin Sensitivity in Overweight and Obese Black Women.

ABSTRACT:

Objective

Weight loss interventions have produced little change in insulin sensitivity in black women, but mean data may obscure metabolic benefit to some and adverse effects for others. Accordingly, we analyzed insulin sensitivity relative to fat mass change following a weight loss program.

Design and methods

Fifty-four black women (BMI range 25.9 to 54.7 kg/m²) completed the 6-month program that included nutrition information and worksite exercise facilities. Fat mass was measured by dual-energy X-ray absorptiometry, and insulin sensitivity index (S_I) was calculated from an insulin-modified intravenous glucose tolerance test using the minimal model.

Results

Baseline S_I (range 0.74 to 7.58 l/mU^-1•min^-1) was inver

SUBMITTER: Leon B 

PROVIDER: S-EPMC4125812 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature