Parental social responsiveness and risk of autism spectrum disorder in offspring.

ABSTRACT:

Importance

Although autism spectrum disorder (ASD) is known to be heritable, patterns of inheritance of subclinical autistic traits in nonclinical samples are poorly understood.

Objective

To examine the familiality of Social Responsiveness Scale (SRS) scores of individuals with and without ASD.

Design, setting, and participants

We performed a nested case-control study (pilot study: July 1, 2007, through June 30, 2009; full-scale study: September 15, 2008, through September 14, 2012) within a population-based longitudinal cohort. Participants were drawn from the Nurses' Health Study II, a cohort of 116,430 female nurses recruited in 1989. Case participants were index children with reported ASD; control participants were frequency matched by year of birth of case partic

SUBMITTER: Lyall K 

PROVIDER: S-EPMC4126195 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature