Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders.

ABSTRACT: Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platele

SUBMITTER: Noris P 

PROVIDER: S-EPMC4126341 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature