Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry.

ABSTRACT:

Objectives

To determine whether epigenetic markers predict dimensional ratings of depression in maltreated children.

Method

A genome-wide methylation study was completed using the Illumina 450K BeadChip array in 94 maltreated and 96 healthy nontraumatized children with saliva-derived DNA. The 450K BeadChip does not include any methylation sites in the exact location as sites in candidate genes previously examined in the literature, so a test for replication of prior research findings was not feasible.

Results

Methylation in 3 genes emerged as genome-wide-significant predictors of depression: DNA-Binding Protein Inhibitor ID-3 (ID3); Glutamate Receptor, Ionotropic N-methyl-D-aspartate (NMDA) 1 (GRIN1); and Tubulin Polymerization Promoting Protein (TPPP) (p < 5.0 × 10(-

SUBMITTER: Weder N 

PROVIDER: S-EPMC4126411 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature