A systematic review and meta-analysis of diagnostic and prognostic serum biomarkers of colorectal cancer.

ABSTRACT:

Background

Our systematic review summarizes the evidence concerning the accuracy of serum diagnostic and prognostic tests for colorectal cancer (CRC).

Methods

The databases MEDLINE and EMBASE were searched iteratively to identify the relevant literature for serum markers of CRC published from 1950 to August 2012. The articles that provided adequate information to meet the requirements of the meta-analysis of diagnostic and prognostic markers were included. A 2-by-2 table of each diagnostic marker and its hazard ratio (HR) and the confidence interval (CI) of each prognostic marker was directly or indirectly extracted from the included papers, and the pooled sensitivity and specificity of the diagnostic marker and the pooled HR and the CI of the prognostic marker were subseque

SUBMITTER: Liu Z 

PROVIDER: S-EPMC4126674 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature