Cellular proteins associated with the interior and exterior of vesicular stomatitis virus virions.

ABSTRACT: Virus particles (virions) often contain not only virus-encoded but also host-encoded proteins. Some of these host proteins are enclosed within the virion structure, while others, in the case of enveloped viruses, are embedded in the host-derived membrane. While many of these host protein incorporations are likely accidental, some may play a role in virus infectivity, replication and/or immunoreactivity in the next host. Host protein incorporations may be especially important in therapeutic applications where large numbers of virus particles are administered. Vesicular stomatitis virus (VSV) is the prototypic rhabdovirus and a candidate vaccine, gene therapy and oncolytic vector. Using mass spectrometry, we previously examined cell type dependent host protein content of VSV virions using in

SUBMITTER: Moerdyk-Schauwecker M 

PROVIDER: S-EPMC4126742 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature