A review of the effects of artemether-lumefantrine on gametocyte carriage and disease transmission.

ABSTRACT: While significant advances have been made in the prevention and treatment of malaria in recent years, these successes continue to fall short of the World Health Organization (WHO) goals for malaria control and elimination. For elimination strategies to be effective, limited disease transmission, achieved through rapid reduction in the infectious parasite reservoir and decreased gametocyte carriage, will be critical. Artemisinin-based combination therapy (ACT) forms the cornerstone of WHO-recommended treatment for uncomplicated Plasmodium falciparum malaria, and in combination with other effective interventions will undoubtedly play a vital role in elimination programmes. The gametocytocidal properties of artemisinins are a bonus attribute; there is epidemiological evidence of reductions in

SUBMITTER: Makanga M 

PROVIDER: S-EPMC4126813 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature