Effect of selenium supplementation on HIV-1 RNA detection in breast milk of Tanzanian women.

ABSTRACT:

Objective

Selenium supplementation for women infected with HIV may increase genital shedding of HIV-1, however, to our knowledge, no studies have examined the effect on viral shedding in breast milk. The aim of this study was to determine the effect of selenium supplementation on HIV-1 RNA detection in breast milk of HIV-infected women.

Methods

HIV-infected pregnant women enrolled at 12 to 27 wk gestation in a randomized, double-blind, placebo-controlled trial of daily selenium (200 μg as selenomethionine) had cell-free HIV-1 RNA quantified in breast milk at 4 to 9 wk postpartum. All participants received high-dose multivitamins containing vitamin B complex, C, and E as standard of care.

Results

The proportion of women with detectable (>50 copies/mL) HIV-1 RNA in brea

SUBMITTER: Sudfeld CR 

PROVIDER: S-EPMC4127095 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature