A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation.

ABSTRACT: Brown and beige/brite fats generate heat via uncoupled respiration to defend against cold. The total mass and activity of thermogenic adipose tissues are also tightly linked to systemic energy and nutrient homeostasis. Despite originating from distinct progenitors, brown and beige adipocytes acquire remarkably similar molecular and metabolic characteristics during differentiation through the action of a network of transcription factors and cofactors. How this regulatory network interfaces with long noncoding RNAs (lncRNAs), an emerging class of developmental regulators, remains largely unexplored. Here, we globally profiled lncRNA gene expression during thermogenic adipocyte formation and identified Brown fat lncRNA 1 (Blnc1) as a nuclear lncRNA that promotes brown and beige adipocyte diff

SUBMITTER: Zhao XY 

PROVIDER: S-EPMC4127104 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature