A rare variant association test based on combinations of single-variant tests.

ABSTRACT: Next generation sequencing technologies make direct testing rare variant associations possible. However, the development of powerful statistical methods for rare variant association studies is still underway. Most of existing methods are burden and quadratic tests. Recent studies show that the performance of each of burden and quadratic tests depends strongly upon the underlying assumption and no test demonstrates consistently acceptable power. Thus, combined tests by combining information from the burden and quadratic tests have been proposed recently. However, results from recent studies (including this study) show that there exist tests that can outperform both burden and quadratic tests. In this article, we propose three classes of tests that include tests outperforming both burden and

SUBMITTER: Sha Q 

PROVIDER: S-EPMC4127117 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature