You are the danger: attenuated insula response in methamphetamine users during aversive interoceptive decision-making.

ABSTRACT:

Background

Drug dependent individuals often make drug-taking decisions when they do not feel well. Yet, few studies have examined the influence of an aversive state on decision-making related neural processing.

Methods

We investigate brain activation to decision-making during an aversive interoceptive challenge in methamphetamine users using functional magnetic resonance imaging (fMRI). Recently abstinent inpatients with methamphetamine use disorder (METH; n=20) and healthy comparison subjects (CTL; n=22) performed a two-choice prediction task at three fixed error rates (ER; 20%=reward, 50%=uncertainty, 80%=punishment) while anticipating and experiencing episodes of inspiratory breathing load during fMRI.

Results

METH exhibited higher trait anxiety in conjunction with

SUBMITTER: Stewart JL 

PROVIDER: S-EPMC4127120 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature