Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.

ABSTRACT:

Background

The age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high-risk families from the Collaborative Study on the Genetics of Alcoholism (COGA).

Methods

Genomewide SNP genotyping was performed in 1788 regular drinkers from 118 large European American families densely affected with alcoholism. We used a genome-wide Cox proportional hazards regression model to test for association between age at onset of AD and SNPs.

Results

This family-based analysis identified an intergenic SNP, rs2168784 on chromosome 3 that showed strong evidence of association (P=5×10(-9)) with age at onset of AD

SUBMITTER: Kapoor M 

PROVIDER: S-EPMC4127128 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature