Coronary microvascular dysfunction is related to abnormalities in myocardial structure and function in cardiac amyloidosis.

ABSTRACT:

Objectives

The purpose of this study was to test the hypothesis that coronary microvascular function is impaired in subjects with cardiac amyloidosis.

Background

Effort angina is common in subjects with cardiac amyloidosis, even in the absence of epicardial coronary artery disease (CAD).

Methods

Thirty-one subjects were prospectively enrolled in this study, including 21 subjects with definite cardiac amyloidosis without epicardial CAD and 10 subjects with hypertensive left ventricular hypertrophy (LVH). All subjects underwent rest and vasodilator stress N-13 ammonia positron emission tomography and 2-dimensional echocardiography. Global left ventricular myocardial blood flow (MBF) was quantified at rest and during peak hyperemia, and coronary flow reserve (CFR) was co

SUBMITTER: Dorbala S 

PROVIDER: S-EPMC4127145 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature