Evaluating 17 breast cancer susceptibility loci in the Nashville breast health study.

ABSTRACT:

Background

Genome-wide association studies have discovered multiple genetic loci associated with breast cancer risk. Investigating these loci would be helpful to evaluate previous findings and identify causal variants for breast cancer. We evaluated index SNPs in 17 of these loci in a study of 1,511 cases and 1,454 controls of European descent.

Methods

We investigated the overall association with breast cancer and among subtypes defined as ER+ (estrogen receptor positive), ER- (estrogen receptor negative) and triple-negative breast cancer (TNBC). Combined effects of SNPs on breast cancer risk were assessed via a genetic risk score. We evaluated the contribution of both genetic variants and traditional risk factors to a breast cancer risk assessment model.

Results

Five

SUBMITTER: Han MR 

PROVIDER: S-EPMC4127164 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature