Risk of hypercalcemia in blacks taking hydrochlorothiazide and vitamin D.

ABSTRACT:

Introduction

Hydrochlorothiazide, an effective antihypertensive medication commonly prescribed to blacks, decreases urinary calcium excretion. Blacks have significantly higher rates of hypertension and lower levels of 25-hydroxyvitamin D. Thus, they are more likely to be exposed to vitamin D supplementation and thiazide diuretics. The risk for hypercalcemia among blacks using vitamin D and hydrochlorothiazide is undefined.

Methods

We assessed the frequency of hypercalcemia in hydrochlorothiazide users in a post hoc analysis of a randomized, double-blind, dose-finding trial of 328 blacks (median age 51 years) assigned to either placebo, or 1000, 2000, or 4000 international units of cholecalciferol (vitamin D3) daily for 3 months during the winter (2007-2010).

Results

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SUBMITTER: Chandler PD 

PROVIDER: S-EPMC4127365 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature