Altered resting state connectivity of the insular cortex in individuals with fibromyalgia.

ABSTRACT:

Unlabelled

The insular cortex (IC) and cingulate cortex (CC) are critically involved in pain perception. Previously we demonstrated that fibromyalgia (FM) patients have greater connectivity between the insula and default mode network at rest, and that changes in the degree of this connectivity were associated with changes in the intensity of ongoing clinical pain. In this study we more thoroughly evaluated the degree of resting-state connectivity to multiple regions of the IC in individuals with FM and healthy controls. We also investigated the relationship between connectivity, experimental pain, and current clinical chronic pain. Functional connectivity was assessed using resting-state functional magnetic resonance imaging in 18 FM patients and 18 age- and sex-matched healthy con

SUBMITTER: Ichesco E 

PROVIDER: S-EPMC4127388 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature