Gene expression signatures affected by ethanol and/or nicotine in normal human normal oral keratinocytes (NHOKs).

ABSTRACT: It has been reported that nicotine/alcohol alter epigenetic control and lead to abrogated DNA methylation and histone modifications, which could subsequently perturb transcriptional regulation critically important in cellular transformation. The aim of this study is to determine the molecular mechanisms of nicotine/alcohol-induced epigenetic alterations and their mechanistic roles in transcriptional regulation in human adult stem cells. We hypothesized that nicotine/alcohol induces deregulation of epigenetic machinery and leads to epigenetic alterations, which subsequently affect transcriptional regulation in oral epithelial stem cells. As an initiating step we have profiled transcriptomic alterations induced by combinatory administration of EtOH and nicotine in primary normal human oral k

SUBMITTER: Kim JJ 

PROVIDER: S-EPMC4127651 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature