Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation.

ABSTRACT: The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbours specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17-producing γδ T (γδT17) cells, the aberrant activation of which by IL-23 can provoke psoriasis-like inflammation. The skin is also innervated by a meshwork of peripheral nerves consisting of relatively sparse autonomic and abundant sensory fibres. Interactions between the autonomic nervous system and immune cells in lymphoid organs are known to contribute to systemic immunity, but how peripheral nerves regulate cutaneous immune responses remains unclear. We exposed the skin of mice to imiquimod, which induces IL-23-dependent psoriasis-like infl

SUBMITTER: Riol-Blanco L 

PROVIDER: S-EPMC4127885 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature