Relaxed selection drives a noisy noncoding transcriptome in members of the Mycobacterium tuberculosis complex.

ABSTRACT: Related species are often used to understand the molecular underpinning of virulence through examination of a shared set of biological features attributable to a core genome of orthologous genes. An important but insufficiently studied issue, however, is the extent to which the regulatory architectures are similarly conserved. A small number of studies have compared the primary transcriptomes of different bacterial species, but few have compared closely related species with clearly divergent evolutionary histories. We addressed the impact of differing modes of evolution within the genus Mycobacterium through comparison of the primary transcriptome of M. marinum with that of a closely related lineage, M. bovis. Both are thought to have evolved from an ancestral generalist species, with M. b

SUBMITTER: Dinan AM 

PROVIDER: S-EPMC4128351 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature