Defining gene-phenotype relationships in Acinetobacter baumannii through one-step chromosomal gene inactivation.

ABSTRACT: Rates of infection with hospital-acquired Acinetobacter baumannii have exploded over the past decade due to our inability to limit persistence and effectively treat disease. A. baumannii quickly acquires antibiotic resistance, and its genome encodes mechanisms to tolerate biocides and desiccation, which enhance its persistence in hospital settings. With depleted antibiotic options, new methods to treat A. baumannii infections are desperately needed. A comprehensive understanding detailing A. baumannii cellular factors that contribute to its resiliency at genetic and mechanistic levels is vital to the development of new treatment options. Tools to rapidly dissect the A. baumannii genome will facilitate this goal by quickly advancing our understanding of A. baumannii gene-phenotype relations

SUBMITTER: Tucker AT 

PROVIDER: S-EPMC4128354 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature