Bim polymorphisms: influence on function and response to treatment in children with acute lymphoblastic leukemia.

ABSTRACT:

Purpose

Corticosteroids induce apoptosis in the malignant lymphoid cells and are critical component of combination therapy for acute lymphoblastic leukemia (ALL). Several genome-wide microarray studies showed major implication of proapoptotic Bim in mediating corticosteroid-related resistance in leukemia cells.

Experimental design

We investigated Bim gene polymorphisms and their association with childhood ALL outcome, and the mechanism underlying the observed finding.

Results

Lower overall survival (OS) was associated with Bim C29201T located in Bcl-2 homology 3 (BH3) domain (P = 0.01). An association remained significant in multivariate model (P = 0.007), was more apparent in high-risk patients (P = 0.004) and patients treated with dexamethasone (P = 0.009), and was

SUBMITTER: Gagne V 

PROVIDER: S-EPMC4128417 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature