The emerging genomic landscape of endometrial cancer.

ABSTRACT:

Background

Endometrial cancer is responsible for approximately 74 000 deaths annually among women worldwide. It is a heterogeneous disease comprising multiple histologic subtypes. In the US, the majority of deaths from endometrial carcinoma are attributed to the serous and endometrioid subtypes. An understanding of the fundamental genomic alterations that drive serous and endometrioid endometrial carcinomas lays the foundation for the identification of molecular markers that could improve the clinical management of patients presenting with these tumors.

Content

We review the current state of knowledge regarding somatic genomic alterations that occur in serous and endometrioid endometrial tumors. We present this knowledge in a historical context by reviewing the genomic alter

SUBMITTER: Le Gallo M 

PROVIDER: S-EPMC4128551 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature