Rcor2 underexpression in senescent mice: a target for inflammaging?

ABSTRACT:

Background

Aging is characterized by a low-grade systemic inflammation that contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). However, little knowledge is currently available on the molecular processes leading to chronic neuroinflammation. In this context, recent studies have described the role of chromatin regulators in inflammation and longevity including the REST corepressor (Rcor)-2 factor, which seems to be involved in an inflammatory suppressive program.

Methods

To assess the impact of Rcor2 in age-related inflammation, gene expression levels were quantified in different tissues and ages of the spontaneous senescence-accelerated P8 mouse (P8) using the SAMR1 mouse (R1) as a control. Specific siRNA transfection in P8 and R1

SUBMITTER: Alvarez-Lopez MJ 

PROVIDER: S-EPMC4128581 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature