Identification of gene-based responses in human blood cells exposed to alpha particle radiation.

ABSTRACT:

Background

The threat of a terrorist-precipitated nuclear event places humans at danger for radiological exposures. Isotopes which emit alpha (α)-particle radiation pose the highest risk. Currently, gene expression signatures are being developed for radiation biodosimetry and triage with respect to ionizing photon radiation. This study was designed to determine if similar gene expression profiles are obtained after exposures involving α-particles.

Methods

Peripheral blood mononuclear cells (PBMCs) were used to identify sensitive and robust gene-based biomarkers of α-particle radiation exposure. Cells were isolated from healthy individuals and were irradiated at doses ranging from 0-1.5 Gy. Microarray technology was employed to identify transcripts that were differentially ex

SUBMITTER: Chauhan V 

PROVIDER: S-EPMC4128605 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature