Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial.

ABSTRACT:

Background

Short-duration studies show that salsalate improves glycemia in type 2 diabetes mellitus (T2DM).

Objective

To assess 1-year efficacy and safety of salsalate in T2DM.

Design

Placebo-controlled, parallel trial; computerized randomization and centralized allocation, with patients, providers, and researchers blinded to assignment. (ClinicalTrials.gov: NCT00799643).

Setting

3 private practices and 18 academic centers in the United States.

Patients

Persons aged 18 to 75 years with fasting glucose levels of 12.5 mmol/L or less (≤225 mg/dL) and hemoglobin A1c (HbA1c) levels of 7.0% to 9.5% who were treated for diabetes.

Intervention

286 participants were randomly assigned (between January 2009 and July 2011) to 48 weeks of placebo (n = 140) or

SUBMITTER: Goldfine AB 

PROVIDER: S-EPMC4128629 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature