Predictors and biomarkers of treatment gains in a clinical stroke trial targeting the lower extremity.

ABSTRACT:

Background and purpose

Behavioral measures are often used to distinguish subgroups of patients with stroke (eg, to predict treatment gains, stratify clinical trial enrollees, or select rehabilitation therapy). In studies of the upper extremity, measures of brain function using functional magnetic resonance imaging (fMRI) have also been found useful, but this approach has not been examined for the lower extremity. The current study hypothesized that an fMRI-based measure of cortical function would significantly improve prediction of treatment-induced lower extremity behavioral gains. Biomarkers of treatment gains were also explored.

Methods

Patients with hemiparesis 1 to 12 months after stroke were enrolled in a double-blind, placebo-controlled, randomized clinical trial of r

SUBMITTER: Burke E 

PROVIDER: S-EPMC4129459 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature